Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.

@article{Mu1995AdministrationOR,
  title={Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.},
  author={Jie Mu and J P Zou and Norio Yamamoto and Takeki Tsutsui and X G Tai and Masataka Kobayashi and Steven H Herrmann and Hiromi Fujiwara and Toshiyuki Hamaoka},
  journal={Cancer research},
  year={1995},
  volume={55 19},
  pages={4404-8}
}
The present study investigates the ability of recombinant interleukin 12 (rIL-12) to modulate the growth of a primary tumor as well as the outgrowth of metastatic tumor cells in an ovarian carcinoma (OV-HM) model. This aggressive tumor displayed rapid growth of the primary tumor mass, high incidence of metastases to lung and lymph nodes, and invasion from the primary s.c. site to the peritoneal cavity. Starting 12 days after s.c. tumor cell implantation, several i.p. injections of rIL-12 at 2-3… CONTINUE READING