Administration of recombinant erythropoietin determines increase of peripheral resistances in patients with hypovolemic shock.

@article{Allegra1996AdministrationOR,
  title={Administration of recombinant erythropoietin determines increase of peripheral resistances in patients with hypovolemic shock.},
  author={Alessandro Allegra and Anastasia Galasso and Licia Vanessa Siracusano and Calmela Aloisi and Francesco Corica and Angela Lagan{\`a} and Nicola Frisina and Michele Buemi},
  journal={Nephron},
  year={1996},
  volume={74 2},
  pages={
          431-2
        }
}
Administration of Recombinant Erythropoietin Determines Increase of Peripheral Resistances in Patients with Hypovolemic Shock A. Alessandro Allegra A. Anselmo Galasso L. Luca Siracusano C. Carmela Aloisi F. Francesco Corica A. Angela Laganà N. Nicola Frisina M. Michele Buemi Internal Medicine Department, Messina University, Medical Pathology I, Anesthesia and Resuscitation Department, Catanzaro Hospital, Anesthesia and Resuscitation Department, Polyclinic, Messina, Italy 
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References

SHOWING 1-10 OF 12 REFERENCES
Recombinant human erythropoietin inhibits the cutaneous vasodilatation induced by acetylcholine.
TLDR
The data suggest that rHuEPO exerts an indirect vasoconstrictive effect and that acetylcholine-induced vasodilatation, which is endothelium-dependent, is blunted by the vasoconStrictive activity of r HuEPO, thus demonstrating that the hormone may impair the synthesis of endothelial nitric oxide.
Platelet-activating factor and cytokine interactions in shock.
Cachectin: a hormone that triggers acute shock and chronic cachexia.
Septic shock and invasive infection are diseases caused by humoral mediators of both exogenous and endogenous origin. The search for and identification of these factors has led to the discovery and…
Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.
TLDR
Results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans.
Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin.
TLDR
It is suggested that endothelial cell-derived nitric oxide plays a role in the development of hypotension in patients treated with tumor necrosis factor or interleukins and that administration of substrate analogues such as L-NMMA may favorably alter the toxicity associated with these immunomodulators and result in a higher maximum tolerated dose, with subsequent improvement in the antitumor activity.
Inhibition of Interleukin-1-α-Induced Nitric Oxide Synthase in Vascular Smooth Muscle and Full Reversal of Interleukin-1-α-Induced Hypotension by Nω-Amino-L-arginine
TLDR
Investigation of the role of nitric oxide (NO.) as a possible mediator of hypotension in IL-1-activated rat aortic smooth muscle cells indicates that vascular smooth muscle is a likely source as well as a target of IL- 1-induced NO, and administration of inhibitors of Nitric oxide synthase inhibitors can fully reverse this hypotension.
Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells
Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism.
Antihypertensive Effect of Interleukin‐2
TLDR
A single bolus of interleukin-2 prevented the increase of blood pressure in the young spontaneously hypertensive rat (SHR) and lowered pressure to normotensive levels in the well-established hypertensive adult SHR.
Eritropoietina ricombinante ed ipertensione arteriosa
  • Ital Nefrol
  • 1990
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