Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system

  title={Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system},
  author={Yang Zhou and Lili Song and Shousheng Ni and Yu Alex Zhang and Shicui Zhang},
One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Current studies have generated disputes on the effects of GDF11 and GDF8, a closely related member of GDF11, on rejuvenation and anti-aging properties. In this study, we first demonstrated that when recombinant GDF8 (rGDF8) and GDF11 (rGDF11) of the fish Nothobranchius guentheri were injected into 20-month-old male mice, their serum GDF8 and GDF11 levels were clearly increased. We also… 
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