Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.

@article{Wang2004AdministrationOP,
  title={Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.},
  author={Ying Wang and Ji Xiao Zhu and Ling Dong Kong and Cheng Yang and Christopher Hon Ki Cheng and Xin Zhang},
  journal={Basic & clinical pharmacology & toxicology},
  year={2004},
  volume={94 5},
  pages={232-7}
}
In this study we have investigated the effects of administration of procyanidins from grape seeds on serum uric acid levels in a model of hyperuricaemia in mice pretreated with oxonate, as well as the xanthine dehydrogenase and xanthine oxidase activities in mouse liver in vivo. The procyanidins, when orally administered to the oxonate-pretreated hyperuricaemic mice, were able to elicit a dose-dependent hypouricaemic effect. At a dose of 400 mg/kg for 3 days, the serum urate levels of the… CONTINUE READING

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