Administration of plasmid DNA expressing human interleukin-6 significantly improves thrombocytopoiesis in irradiated mice

@article{Sun2001AdministrationOP,
  title={Administration of plasmid DNA expressing human interleukin-6 significantly improves thrombocytopoiesis in irradiated mice},
  author={Ling Sun and Xiaowei Liu and L. Qiu and Jia-xi Wang and Min Liu and Dongtao Fu and Qing-liang Luo},
  journal={Annals of Hematology},
  year={2001},
  volume={80},
  pages={567-572}
}
When people are exposed to large doses of ionizing rays in a short time, hematopoiesis is impaired and hemorrhage is one of the major clinical features. Suddenly decreasing platelet counts are responsible for the life-threatening hemorrhagic complication. Therefore, some cytokines have been used to improve thrombocytopoiesis in various radiation-induced thrombocytopenia models. Current measures for this purpose involve repeated intravenous or subcutaneous injections of recombinant proteins… CONTINUE READING