Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice.

@article{Ludviksson1999AdministrationOM,
  title={Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice.},
  author={Bjorn Runar Ludviksson and Warren Strober and Ryuta Nishikomori and Syed Kazim Hasan and Rolf O. Ehrhardt},
  journal={Journal of immunology},
  year={1999},
  volume={162 8},
  pages={
          4975-82
        }
}
We previously demonstrated that 2,4,6-trinitrophenol (TNP)-OVA immunization leads to a transmural colitis in the IL-2-/- mouse that is caused by IL-12-driven CD4+ Th1 T cells and resembles human Crohn's disease. The integrin alpha E beta 7 is highly expressed on colonic intraepithelial lymphocytes and has been suggested to function as a homing or retention molecule for intraepithelial lymphocytes. To evaluate the role of alpha E beta 7 in colitis, we administered a mAb against alpha E beta 7 to… CONTINUE READING

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