Administration of ketamine for unipolar and bipolar depression

@article{Kraus2017AdministrationOK,
  title={Administration of ketamine for unipolar and bipolar depression},
  author={Christoph Kraus and Ulrich Rabl and Thomas Vanicek and Laura Carlberg and Ana Popovic and Marie Spies and Lucie Bartova and Gregor Gryglewski and Konstantinos Papageorgiou and Rupert Lanzenberger and Matth{\"a}us Willeit and Dietmar Winkler and Janusz K. Rybakowski and Siegfried Kasper},
  journal={International Journal of Psychiatry in Clinical Practice},
  year={2017},
  volume={21},
  pages={12 - 2}
}
  • C. Kraus, U. Rabl, S. Kasper
  • Published 2 January 2017
  • Psychology
  • International Journal of Psychiatry in Clinical Practice
Abstract Objective: Clinical trials demonstrated that ketamine exhibits rapid antidepressant efficacy when administered in subanaesthetic dosages. We reviewed currently available literature investigating efficacy, response rates and safety profile. Methods: Twelve studies investigating unipolar, seven on bipolar depression were included after search in medline, scopus and web of science. Results: Randomized, placebo-controlled or open-label trials reported antidepressant response rates after 24… 
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References

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TLDR
A rapid antidepressant effect of ketamine infusion maintaining for 2 weeks is confirmed, in a considerable proportion of patients with bipolar depression, and good clinical tolerance of such procedure is shown.
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TLDR
In this relatively large group of patients with TRD, ketamine was safe and well tolerated and further research investigating the safety of ketamine in severe and refractory depression is warranted.
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TLDR
The ketamine infusion was effective in reducing the HDRS scores, and the change remained significant from minute 80 to day 3 postinfusion at each time point, but the change was not significant at any time after day 3.
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TLDR
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TLDR
A substantial relationship between ketamine's antidepressant and psychotomimetic effects was found, and this relationship could be mediated by the initial steps of ketamine’s action, trough NMDA receptors, shared by both ketamines' clinical effects.
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