Administration of insulin–like growth factor–1 (IGF–1) improves both structure and function of delta–sarcoglycan deficient cardiac muscle in the hamster

@article{Serose2004AdministrationOI,
  title={Administration of insulin–like growth factor–1 (IGF–1) improves both structure and function of delta–sarcoglycan deficient cardiac muscle in the hamster},
  author={Armelle Serose and Bernard Prudhon and Andr{\'e} Salmon and M.-A. Doyennette and Marc Y Fiszman and PhD Y. Fromes},
  journal={Basic Research in Cardiology},
  year={2004},
  volume={100},
  pages={161-170}
}
Dilated cardiomyopathies (DCM) are due to progressive dilatation of the cardiac cavities and thinning of the ventricular walls and lead unavoidably to heart failure. They represent a major cause for heart transplantation and, therefore, defining an efficient symptomatic treatment for DCM remains a challenge. We have taken advantage of the hamster strain CHF147 that displays progressive cardiomyopathy leading to heart failure to test whether stimulation of a hypertrophic pathway could delay the… CONTINUE READING
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