Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen-induced liver failure.

@article{Francavilla1993AdministrationOH,
  title={Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen-induced liver failure.},
  author={Antonio Francavilla and Alessandro Azzarone and G Carrieri and Umberto Cillo and David Van Thiel and V Subbottin and Thomas E. Starzl},
  journal={Hepatology},
  year={1993},
  volume={17 3},
  pages={429-33}
}
Sixty-two beagle dogs were given three doses of acetaminophen over a period of 24 hr in a fulminant liver failure model that is 70% lethal in 72 hr. Treatment of the animals with hepatic stimulatory substance alone or in a mixture with insulin, transforming growth factor-alpha and insulin-like growth factor II had no effect on mortality. Evidence of maximum regeneration with a mitotic index 20 to 25 times resting was the same in treated and untreated animals. Similarly, the biochemical and… CONTINUE READING