Administration of half-dose theophylline together with ketotifen to asthmatic children--a double-blind, placebo-controlled study.

@article{Volovitz1994AdministrationOH,
  title={Administration of half-dose theophylline together with ketotifen to asthmatic children--a double-blind, placebo-controlled study.},
  author={Benjamin Volovitz and Jacob Amir and Hana Malik and Michael Lerman and Izhak Varsano},
  journal={The Journal of asthma : official journal of the Association for the Care of Asthma},
  year={1994},
  volume={31 1},
  pages={27-34}
}
Administration of theophylline to asthmatic children is frequently associated with an adverse influence on their behavior. The efficacy and behavioral effects of the administration of high-dose theophylline (T) and ketotifen (K) in various combinations were evaluated prospectively in a double-blind, placebo controlled study in 55 children with moderately severe perennial asthma. During a baseline period of 2 weeks, theophylline (serum level of 10-20 micrograms/ml) was administered to all the… CONTINUE READING