Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.

@article{Martina2001AdministrationOG,
  title={Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.},
  author={Valentino Martina and Guido Albino Bruno and Ester Zumpano and Carla Origlia and Lavinia Quaranta and Gian Piero Pescarmona},
  journal={Journal of endocrinological investigation},
  year={2001},
  volume={24 1},
  pages={37-41}
}
Several studies suggest that nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to cardiovascular mortality. Furthermore, NO synthesis is impaired in glutathione (GSH)-depleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes mellitus (T2DM). We tested the hypothesis that treatment with GSH may improve platelet constitutive NO sinthase (cNOS) activity in patients with T2DM. Fifteen patients with T2DM… CONTINUE READING

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