Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.

Abstract

Several studies suggest that nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to cardiovascular mortality. Furthermore, NO synthesis is impaired in glutathione (GSH)-depleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes mellitus (T2DM). We tested the hypothesis… (More)

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@article{Martina2001AdministrationOG, title={Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.}, author={Valentino Martina and Giuseppe Bruno and Ester Zumpano and Carla Origlia and Luciano Quaranta and Gian Piero Pescarmona}, journal={Journal of endocrinological investigation}, year={2001}, volume={24 1}, pages={37-41} }