Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development

@article{Li2012AdministrationOG,
  title={Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development},
  author={Yan Li and Jie Hai and Lake Li and Xuehui Chen and Hua Peng and Meng Zhu Cao and Qinggui Zhang},
  journal={Endocrine},
  year={2012},
  volume={43},
  pages={376-386}
}
We aim to investigate the preventive and therapeutic effects of ghrelin on a rat NAFLD model and possible underlying mechanism. Sprague–Dawley rats were fed with high-fat diet for 8 weeks to induce NAFLD. A group of rats were also treated with ghrelin throughout the NAFLD induction. After 8 weeks, rats were sacrificed for liver injury measurements. Rats with NAFLD showed obvious histological changes including necrosis and inflammation foci, elevated serum enzyme (ALT and AST) levels… CONTINUE READING
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