Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles.

@article{Malberg1997AdministrationOF,
  title={Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles.},
  author={Jessica E. Malberg and Lewis S. Seiden},
  journal={Brain research},
  year={1997},
  volume={765 1},
  pages={101-7}
}
This study investigated the effect of two different ambient temperatures on fenfluramine-induced 5-HT neurotoxicity. Fenfluramine (FEN) (12.5 mg/kg x 4; injections made hourly) or saline (SAL) was administered to rats in either a normal laboratory temperature of 24 degrees C or a warm environment of 30 degrees C. Animals were kept at that ambient temperature for 20 h after FEN administration. Ambient temperature was controlled to +/-0.5 degrees C and rat core temperature was continually… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…