Administration of anti-c-kit antibody into the cerebrospinal fluid leads to increased cell death in the developing cerebral cortex.

@article{Mashayekhi2011AdministrationOA,
  title={Administration of anti-c-kit antibody into the cerebrospinal fluid leads to increased cell death in the developing cerebral cortex.},
  author={Farhad Mashayekhi and Lida Gholizadeh},
  journal={Saudi journal of biological sciences},
  year={2011},
  volume={18 3},
  pages={261-6}
}
It is generally believed that during development, neurons are usually produced in excess. Cell death occurs in the developing nervous system. The survival of the developing neurons depends on many factors derived from the target sites, of which the neuronal trophic factors are by far the best known. Stem cell factor (SCF) and its receptor, c-kit, is expressed in cells of nervous system during development and adulthood. Although the role of SCF/c-kit in the nervous system is so far not clear, in… CONTINUE READING