Administration of anti-IL-4 monoclonal antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection.

@article{HaakFrendscho1992AdministrationOA,
  title={Administration of anti-IL-4 monoclonal antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection.},
  author={Mary Haak-Frendscho and James F. Brown and Y Iizawa and R Doug Wagner and Charles J. Czuprynski},
  journal={Journal of immunology},
  year={1992},
  volume={148 12},
  pages={3978-85}
}
The role of endogenous IL-4 in resistance to Listeria monocytogenes infection was investigated by in vivo administration of an anti-IL-4 mAb (11B11). Mice treated with 0.01 to 0.4 mg of anti-IL-4 mAb before L. monocytogenes challenge demonstrated a significantly reduced peak bacterial burden in their livers and spleens and accelerated bacterial clearance from these organs. In addition, histopathologic damage to the liver was reduced. Maximal protection was achieved by i.p. injection of 0.1 mg… CONTINUE READING