Administration of an insulin powder to the lungs of cynomolgus monkeys using a Penn Century insufflator.

@article{Grainger2004AdministrationOA,
  title={Administration of an insulin powder to the lungs of cynomolgus monkeys using a Penn Century insufflator.},
  author={Christopher I. Grainger and Robert Alcock and Trevor G Gard and Alan V Quirk and Geert van Amerongen and Rik L de Swart and John George Hardy},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={269 2},
  pages={523-7}
}
A powder formulation of live-attenuated measles vaccine is being developed for administration to the lungs. The safety and efficacy of the powder will be assessed by insufflation into cynomolgus monkeys. A Penn Century insufflator has been evaluated for powder dosing to the monkeys using an insulin formulation having similar physicochemical characteristics to the vaccine powder. Insulin pharmacokinetics were compared following dosing by powder insufflation, solution instillation into the… CONTINUE READING