Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.

@article{Olearczyk2009AdministrationOA,
  title={Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.},
  author={Jeffrey J Olearczyk and Jeffrey E. Quigley and Bradford C. Mitchell and Tatsuo Yamamoto and In-Hae Kim and John W. Newman and Ayala Luria and Bruce D Hammock and John D. Imig},
  journal={Clinical science},
  year={2009},
  volume={116 1},
  pages={61-70}
}
Hypertension and Type 2 diabetes are co-morbid diseases that lead to the development of nephropathy. sEH (soluble epoxide hydrolase) inhibitors are reported to provide protection from renal injury. We hypothesized that the sEH inhibitor AUDA [12-(3-adamantan-1-yl-ureido)-dodecanoic acid] protects the kidney from the development of nephropathy associated with hypertension and Type 2 diabetes. Hypertension was induced in spontaneously diabetic GK (Goto-Kakizaki) rats using AngII (angiotensin II… CONTINUE READING

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