Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.

@article{Laskaris2016AdministrationOZ,
  title={Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.},
  author={Paris Laskaris and Ahmad Atrouni and Jos{\'e} Antonio Calera and Christophe d'Enfert and H{\'e}l{\'e}ne Munier-Lehmann and J. M. Cavaillon and J. P. Latg{\'e} and Ouma{\"i}ma Ibrahim-Granet},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 10},
  pages={
          5631-9
        }
}
Aspergillus fumigatus can infect immunocompromised patients, leading to high mortality rates due to the lack of reliable treatment options. This pathogen requires uptake of zinc from host tissues in order to successfully grow and cause virulence. Reducing the availability of that micronutrient could help treat A. fumigatus infections. In this study, we examined the in vitro effects of seven chelators using a bioluminescent strain of A. fumigatus 1,10-Phenanthroline and N,N,N',N'-tetrakis(2… CONTINUE READING
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