Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.

@article{Lu2014AdministrationOS,
  title={Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.},
  author={Aigang Lu and Kenneth R. Wagner and J P Broderick and J. F. Clark},
  journal={Neuroscience},
  year={2014},
  volume={270},
  pages={40-7}
}
Although intracerebral hemorrhage (ICH) increases the level of glutamate in the perihematomal area and cerebral spinal fluid (CSF) in the ICH acute phase, it is unclear whether elevated glutamate activates neuronal nitric oxide synthase (nNOS) in the ICH brain and whether nNOS is an important target for ICH treatment. Here, we assessed the role of the nNOS inhibitor S-methyl-l-thiocitrulline (SMTC) in the activity of NADPH-d and ICH-induced brain injuries. An autologous blood intracerebral… CONTINUE READING