Administration of LHRH analog can improve working memory in aged female rats.

@article{Alliot1993AdministrationOL,
  title={Administration of LHRH analog can improve working memory in aged female rats.},
  author={Josette Alliot and P Nauton and Maurice Antoine Bruhat},
  journal={Psychoneuroendocrinology},
  year={1993},
  volume={18 8},
  pages={543-50}
}
We had previously found that an age-related deficit in working memory appeared in middle-aged females, possibly related to their ageing reproductive system. This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months. Animals were injected SC with a long-lasting microcapsule formulation (800… CONTINUE READING