Administration of IL-1Ra chitosan nanoparticles enhances the therapeutic efficacy of mesenchymal stem cell transplantation in acute liver failure.

@article{Xiao2013AdministrationOI,
  title={Administration of IL-1Ra chitosan nanoparticles enhances the therapeutic efficacy of mesenchymal stem cell transplantation in acute liver failure.},
  author={Jiang-qiang Xiao and Xiao-lei Shi and Hu-cheng Ma and Jia-jun Tan and Lin-zhang and Qian Xu and Yitao Ding},
  journal={Archives of medical research},
  year={2013},
  volume={44 5},
  pages={370-9}
}
BACKGROUND AND AIMS To investigate the synergistic effect of IL-1Ra administration and stem cell transplantation in swine suffering from acute liver failure (ALF), to elucidate the mechanism of IL-1Ra activity and to demonstrate mesenchymal stem cell (MSC) transplantation as a potential treatment for ALF. METHODS Thirty-five Chinese experimental mini-swine were divided into five groups randomly. Group A (n = 7) is the control group and all swine were injected with saline via portal veins… CONTINUE READING

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