Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.

@article{Voigt2011AdministrationOG,
  title={Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.},
  author={Robin Michelle Voigt and Amy Anne Herrold and Jennifer L. Riddle and T. Celeste Napier},
  journal={Behavioural brain research},
  year={2011},
  volume={216 1},
  pages={419-23}
}
Little is known about the role of GABA(B) receptors (GABA(B)Rs) in the maintenance of memories associated with using abused substances. We have embarked on a series of studies designed to determine if enhancing the efficacy of GABA-occupied GABA(B)Rs with positive allosteric modulators (PAMs) can negate previously established conditioned place preference (CPP) induced by methamphetamine. In the current study, we evaluated the effects of acute administration of GABA(B)R PAMs, GS39783 and CGP7930… CONTINUE READING

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