Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder

  title={Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder},
  author={W. Paul Farquhar-Smith and Andrew S. C. Rice},
Background Referred hyperalgesia to a somatopically appropriate superficial site is a cardinal symptom of visceral inflammatory pain and has been demonstrated after turpentine-induced urinary bladder inflammation in the rat. The authors examined the effect of the endocannabinoids anandamide and palmitoylethanolamide on the referred hyperalgesia associated with this model. Methods After measurement of baseline limb withdrawal latencies to a noxious heat stimulus, the bladders of 50 female Wistar… 
Intrathecal cannabinoid-1 receptor agonist prevents referred hyperalgesia in acute acrolein-induced cystitis in rats.
It is suggested that pain arising from cystitis may be inhibited by activation of spinal CB1R but the acute local response of the bladder appeared to be unaffected by stimulation of spinalCB1R.
Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats
It is revealed that PEA might be effective in relieving inflammatory and neuropathic pain, especially pain induced by mechanical hyperalgesia, but not cold allodynia.
Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy.
A mechanistic discussion of the "framework" for analgesia will be followed by a description of studies examining the role of endocannabinoids in relieving pain; since the elucidation of these effects was undertaken using synthetic cannabinoids, reference will also be made to such studies, in the context of endOCannabinoids.
Local activation of cannabinoid CB1 receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents
Results demonstrate that sensitization of bladder afferents induced by inflammation is partly suppressed by intravesical activation of cannabinoid receptors, an effect that appears to be mediated by CB1 receptors.
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats
  • M. Sansón, L. Buéno, J. Fioramonti
  • Biology, Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2006
It is concluded that colonic inflammation enhances the antinociceptive action of CB1 and CB2 receptor agonists, and activates an endogenous, CB1 receptor mediated, antinOCiceptive pathway.
Potential Future Pharmacological Treatment of Bladder Dysfunction.
  • K. Andersson
  • Biology, Medicine
    Basic & clinical pharmacology & toxicology
  • 2016
Evidence suggests that components of the endocannabinoid system are involved in regulation of bladder function, but the roles of these channels for normal function and in pathological states have not been established, and so far adverse effects (hyperthermia) have hampered development of antagonists.
The role of endocannabinoids and their receptors on the regulation of bladder function and detrusor overactivity
In conclusion, cannabinoid receptors are involved in normal micturition at both peripheral and CNS sites, data supported by in vitro studies where CB1 reduced neuronal activity and where both cannabinoid receptors modulated bladder contractility.
A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors
O-1602 can improve DO, and may serve as a promising novel substance for the pharmacotherapy of bladder diseases and the level of specific biomarkers was examined.


Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent.
Findings increase the knowledge of the nature of visceral and referred pain and further implicate NGF in the hyperalgesic response to inflammation of the urinary bladder.
Antihyperalgesic effects of spinal cannabinoids.
Spinal and supraspinal components of cannabinoid-induced antinociception.
  • A. Lichtman, B. Martin
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1991
The purpose of this study was to investigate whether cannabinoids produce antinociception spinal and supraspinal sites of action. The antinociceptive effect of delta 9-tetrahydrocannabinol (3 or 10
The role of nerve growth factor in a model of visceral inflammation
Control of pain initiation by endogenous cannabinoids
It is shown that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS, and that locally generated an andamide and PEA may mediate this effect.