Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder

@article{FarquharSmith2001AdministrationOE,
  title={Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder},
  author={W. Farquhar-Smith and A. Rice},
  journal={Anesthesiology},
  year={2001},
  volume={94},
  pages={507-513}
}
Background Referred hyperalgesia to a somatopically appropriate superficial site is a cardinal symptom of visceral inflammatory pain and has been demonstrated after turpentine-induced urinary bladder inflammation in the rat. The authors examined the effect of the endocannabinoids anandamide and palmitoylethanolamide on the referred hyperalgesia associated with this model. Methods After measurement of baseline limb withdrawal latencies to a noxious heat stimulus, the bladders of 50 female Wistar… Expand
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