Administration of Drugs Known to Inhibit P-Glycoprotein Increases Brain Bilirubin and Alters the Regional Distribution of Bilirubin in Rat Brain

@article{Hank2003AdministrationOD,
  title={Administration of Drugs Known to Inhibit P-Glycoprotein Increases Brain Bilirubin and Alters the Regional Distribution of Bilirubin in Rat Brain},
  author={Erik Hank\o and Steve Tommarello and Jon F Watchko and Thor W. R Hansen},
  journal={Pediatric Research},
  year={2003},
  volume={54},
  pages={441-445}
}
P-Glycoprotein (P-gp) is an ATP-dependent integral plasma membrane efflux pump, expressed in abundance in brain capillary endothelial cells and astrocytes. P-gp contributes to the blood–brain barrier in limiting the influx and retention of a variety of lipophilic compounds, including unconjugated bilirubin. Several drugs block P-gp function and thereby enhance intracellular accumulation of P-gp substrates. In this study we proposed that pretreatment with drugs known to inhibit P-gp function in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

P-glycoprotein expression in the developing human central nervous system: cellular and tissue localization

  • C Tsai, M Ahdab-Barmada, M Daoood, JF Watchko
  • Pediatr Res:
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…