Administration of ATG according to the absolute T lymphocyte count during therapy for steroid-resistant rejection.

@article{Clark1993AdministrationOA,
  title={Administration of ATG according to the absolute T lymphocyte count during therapy for steroid-resistant rejection.},
  author={Kenneth B. Clark and John L R Forsythe and Brian K. Shenton and Thomas W. J. Lennard and George Proud and Rachel R. Taylor},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={1993},
  volume={6 1},
  pages={18-21}
}
In renal transplantation, treatment of steroid-resistant rejection (SRR) with antithymocyte globulin (ATG) has been widely reported but over-immunosuppression remains a common problem. In the first ten patients (group 1) treated for SRR with rabbit ATG, three developed serious viral infections and two deaths occurred due to CMV pneumonitis. ATG was only omitted if thrombocytopenia or neutropenia occurred. In the next 17 patients (group 2) with SRR, ATG was administered according to the absolute… CONTINUE READING