Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats

@inproceedings{Takakura2017AdministrationFA,
  title={Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats},
  author={Aya Takakura and Ji-Won Lee and Kyoko Hirano and Yukihiro Isogai and Toshinori Ishizuya and Ryoko Takao-Kawabata and Tadahiro Iimura},
  booktitle={Bone Research},
  year={2017}
}
To investigate whether the administration frequency of parathyroid hormone (PTH) is associated with the development of cortical porosity, this study established 15 dosage regimens of teriparatide [human PTH(1–34), TPTD] with four distinct concentrations and four distinct administration frequencies of TPTD to 16-week-old ovariectomized rats. Our analyses demonstrated that the bone mineral density, mechanical properties, and bone turnover were associated with the total amount of TPTD administered… CONTINUE READING
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