Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology.

@article{Bausch1998AdministeredAE,
  title={Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology.},
  author={Suzanne B. Bausch and T M Esteb and Gregory W. Terman and Charles Chavkin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={284 3},
  pages={
          1147-55
        }
}
The effects of kappa opioids on seizures and seizure-induced histopathology were investigated with the pilocarpine model of temporal lobe epilepsy. Rats treated with the kappa opioid receptor agonist U50488h before pilocarpine showed: 1) increased seizure latency; 2) decreased seizure duration; 3) decreased mossy fiber sprouting; and 4) increased hilar neuron survival when compared with rats pretreated with saline. Behavioral effects of U50488h were blocked by the kappa opioid receptor… CONTINUE READING
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