Adjuvanticity of an IL-12 fusion protein expressed by recombinant deltaG-vesicular stomatitis virus.

@article{Klas2002AdjuvanticityOA,
  title={Adjuvanticity of an IL-12 fusion protein expressed by recombinant deltaG-vesicular stomatitis virus.},
  author={Sheri D Klas and Clinton S. Robison and Michael A. Whitt and Mark Andrew Miller},
  journal={Cellular immunology},
  year={2002},
  volume={218 1-2},
  pages={59-73}
}
The remarkable immunomodulatory and adjuvant properties of rIL-12 have been well described. Many early studies documenting the adjuvanticity of IL-12 were performed using the murine model of Listeria monocytogenes infection. In this report, we describe the construction of an attenuated recombinant vesicular stomatitis virus (VSV-deltaG) that encodes a single-chain IL-12 fusion protein (IL-12F), and the use of this virus as an expression vector to produce large quantities of IL-12F. VSV… CONTINUE READING