Adjuvant vigabatrin in refractory epilepsy: a ceiling to effective dosage in individual patients?

@article{McKee1993AdjuvantVI,
  title={Adjuvant vigabatrin in refractory epilepsy: a ceiling to effective dosage in individual patients?},
  author={Paul. McKee and J Blacklaw and Elaine Friel and George G. Thompson and Robert A Gillham and Martin J Brodie},
  journal={Epilepsia},
  year={1993},
  volume={34 5},
  pages={937-43}
}
A double-blind, randomized, cross-over study of additional vigabatrin (gamma-vinyl-GABA, VGB, 1.0 g twice daily for 6 weeks, followed by 1.5 g twice daily for 6 weeks) and matched placebo was undertaken in 24 patients with refractory epilepsy. Nineteen completed the trial satisfactorily. Fewer seizure days were reported during VGB treatment [placebo 41, VGB 23, p < 0.05, 95% confidence interval (CI) -1.5 to -14]. An overall reduction in median seizure numbers failed to reach statistical… CONTINUE READING

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A double - blind , randomized , cross - over study of additional vigabatrin ( gamma - vinyl - GABA , VGB , 1.0 g twice daily for 6 weeks , followed by 1.5 g twice daily for 6 weeks ) and matched placebo was undertaken in 24 patients with refractory epilepsy .
A double - blind , randomized , cross - over study of additional vigabatrin ( gamma - vinyl - GABA , VGB , 1.0 g twice daily for 6 weeks , followed by 1.5 g twice daily for 6 weeks ) and matched placebo was undertaken in 24 patients with refractory epilepsy .
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