Adjuvant treatment of atopic eczema: assessment of an emollient containing N‐palmitoylethanolamine (ATOPA study)

@article{Eberlein2008AdjuvantTO,
  title={Adjuvant treatment of atopic eczema: assessment of an emollient containing N‐palmitoylethanolamine (ATOPA study)},
  author={Bernadette Eberlein and Christoph Eicke and H. Wolfgang Reinhardt and Johannes Ring},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2008},
  volume={22}
}
  • B. Eberlein, C. Eicke, J. Ring
  • Published 10 July 2007
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology
Background  For long‐term management of atopic eczema, the use of skin care creams is recommended, but effectiveness of this treatment is not well established. 
New innovation of moisturizers containing non-steroidal anti-inflammatory agents for atopic dermatitis
TLDR
New innovation of moisturizers containing non-steroidal anti-inflammatory agents for atopic dermatitis is reported, which is a first of its kind in the world.
N‐Acyl ethanolamide and eicosanoid involvement in irritant dermatitis
TLDR
Differing histopathological and clinical features implicate involvement of alternative inflammatory pathways; bioactive lipid mediators are likely candidates for regulation of the divergent inflammatory responses.
Novel cannabidiol aspartame combination treatment (JW‐100) significantly reduces ISGA score in atopic dermatitis: Results from a randomized double‐blinded placebo‐controlled interventional study
TLDR
Various studies have reported on cannabidiol’s effectiveness in relieving pain and easing inflammation while not presenting major health risks.
Severe Itchy Rashes
TLDR
Treatment of atopic dermatitis should be directed at improving the epidermal barrier dysfunction to reduce epicutaneous sensitization and preventing the atopic march to forward.
The effects of treatment on itch in atopic dermatitis
TLDR
Treatments for itch in atopic dermatitis range from simple avoidance of pruritus triggers to more complicated systemic therapy, with the most effective treatments being primarily topical or systemic anti‐inflammatory agents.
Clinical and in vitro evaluation of new anti‐redness cosmetic products in subjects with winter xerosis and sensitive skin
TLDR
In vitro activities of panthenol, palmitoylethanolamide (PEA), and niacinamide (NAM) are demonstrated to demonstrate the biophysical properties, clinical safety, tolerability, and efficacy of two developmental anti‐redness formulations containing these ingredients in alleviating facial redness associated with winter xerosis in healthy volunteers with sensitive skin.
Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone‐induced atopic dermatitis model
TLDR
The effects of CBR agonists on skin inflammation, using acute and chronic inflammation animal models, are investigated.
Current Clinical Options for the Management of Itch in Atopic Dermatitis
TLDR
Currently available treatment options for atopic itch, their available evidence and efficacy, and some of the more recent advancements in the field are discussed.
Evolution of conventional therapy in atopic dermatitis.
...
...

References

SHOWING 1-10 OF 30 REFERENCES
A multicentre, randomized, double‐blind, controlled study of long‐term treatment with 0·1% tacrolimus ointment in adults with moderate to severe atopic dermatitis
TLDR
A large number of patients with AD are receiving topical corticosteroids for atopic dermatis, but prolonged usage can result in skin atrophy and other side‐effects.
On the definition and epidemiology of atopic dermatitis.
Position paper on diagnosis and treatment of atopic dermatitis
TLDR
Evidence for the efficacy of systemic antihistamines in relieving pruritus is still insufficient, but some patients seem to benefit, and ‘Eczema school’ educational programmes have proved to be helpful.
Long-Term Efficacy and Safety of Pimecrolimus Cream 1% in Adults with Moderate Atopic Dermatitis
TLDR
For adults with moderate AD, pimecrolimus cream 1% is well tolerated, reduces the incidence of flares, reduces/eliminates corticosteroid use, improves long-term disease control and enhances the patients’ quality of life.
Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study.
TLDR
The test product appeared to be effective in reducing both pruritus and xerosis in hemodialysis patients and the test product was very well tolerated by all patients.
Topical Steroids under Wet-Wrap Dressings in Atopic Dermatitis – A Vehicle-Controlled Trial
TLDR
Application of the wet-wrap dressing technique for exacerbated AD lesions is effective, combination with a topical steroid being superior to a steroid-free application without bearing the risk of a bacterial superinfection.
Handbook of Atopic Eczema
Atopy: Condition, Disease, or Syndrome?.- The History of Atopic Eczema/Dermatitis.- Epidemiology of Atopic Eczema.- The Burden of Atopic Eczema.- Clinical Symptoms of Atopic Eczema.- Atopic Eczema in
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.
TLDR
It is shown that PEA potently enhances the anti-proliferative effects of AEA on human breast cancer cells (HBCCs), in part by inhibiting the expression of fatty acid amide hydrolase (FAAH), the major enzyme catalysing AEA degradation.
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.
TLDR
It is shown that PEA potently enhances the anti-proliferative effects of AEA on human breast cancer cells (HBCCs), in part by inhibiting the expression of fatty acid amide hydrolase (FAAH), the major enzyme catalysing AEA degradation.
Essential Aspects of Atopic Dermatitis
TLDR
Itch as the Essential Symptom of AD.- 4 Histopathological and Laboratory Findings.- 4.1.1 Mode of Predilection.- 5.1 Itch and Pain.
...
...