Adjuvant neurotrophic factors in peripheral nerve repair with chondroitin sulfate proteoglycan-reduced acellular nerve allografts.

@article{Boyer2015AdjuvantNF,
  title={Adjuvant neurotrophic factors in peripheral nerve repair with chondroitin sulfate proteoglycan-reduced acellular nerve allografts.},
  author={Richard B. Boyer and Kevin W Sexton and Charles L Rodriguez-Feo and Ratnam Nookala and Alonda C. Pollins and Nancy L. Cardwell and Keonna Y Tisdale and Lillian B. Nanney and Robert Bruce Shack and Wesley P. Thayer},
  journal={The Journal of surgical research},
  year={2015},
  volume={193 2},
  pages={969-77}
}
BACKGROUND Acellular nerve allografts are now standard tools in peripheral nerve repair because of decreased donor site morbidity and operative time savings. Preparation of nerve allografts involves several steps of decellularization and modification of extracellular matrix to remove chondroitin sulfate proteoglycans (CSPGs), which have been shown to inhibit neurite outgrowth through a poorly understood mechanism involving RhoA and extracellular matrix-integrin interactions. Chondroitinase ABC… CONTINUE READING