Adjuvant intraoperative photodynamic therapy diminishes the rate of local recurrence in a rat mammary tumour model.

@article{Hillegersberg1995AdjuvantIP,
  title={Adjuvant intraoperative photodynamic therapy diminishes the rate of local recurrence in a rat mammary tumour model.},
  author={Richard van Hillegersberg and J. M. Hekking-Weijma and John P. Wilson and Annie Edixhoven-Bosdijk and W. J. A. De Kort},
  journal={British Journal of Cancer},
  year={1995},
  volume={71},
  pages={733 - 737}
}
The use of photodynamic therapy (PDT) as an adjunct to curative tumour resection was investigated in a tumour recurrence model, using rat mammary adenocarcinoma BN472. Tumours were inoculated subcutaneously in 60 animals and resected after 21 days of growth. Immediately after removal, the operation site was exposed to 320-450 nm light of 0.1 W cm-2 and 60 J cm-2 after photosensitisation with either Photofrin (5 mg kg-1 i.v. 48 h before illumination) or 5-aminolaevulinic acid (ALA) (2 mg ml-1 in… CONTINUE READING

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