Adjuvant-induced arthritis in rats: A possible animal model of chronic pain

@article{Costa1981AdjuvantinducedAI,
  title={Adjuvant-induced arthritis in rats: A possible animal model of chronic pain},
  author={Carlos Maur{\'i}cio de Castro Costa and Jan M. Gybels and Johan Van Hees},
  journal={PAIN},
  year={1981},
  volume={11}
}
Adjuvant-induced arthritic rats were observed clinically and behaviorally. The clinical disease has a duration of greater than 1 month and can be divided into a pre-clinical (1-10 days), an acute (15-30 days), postacute (30-50 days) and a late phase (greater than 50 days). Adjuvant arthritis induces significantly quantitatively changes in the rats' behaviour. Two types of behavioural change merit special attention: freezing (arresting) and scratching. Freezing is significantly increased in the… CONTINUE READING

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