Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial.

@article{Peltola2007AdjuvantGA,
  title={Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial.},
  author={Heikki Peltola and Irmeli Roine and Josefina A Fern{\'a}ndez and In{\'e}s Zavala and Silvia E Gonz{\`a}lez Ayala and Antonio Gonz{\'a}lez Mata and Antonio Arbo and Rosa Bologna and Greta Mi{\~n}o and Jos{\'e} Goyo and Eduardo L{\'o}pez and Solange Dourado de Andrade and Seppo S Sarna},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2007},
  volume={45 10},
  pages={1277-86}
}
BACKGROUND Despite favorable meta-analyses, no study involving third-generation cephalosporins for the treatment of childhood bacterial meningitis has documented a benefit of adjuvant dexamethasone therapy if the outcomes are examined individually. METHODS We conducted a prospective, randomized, double-blind trial comparing adjuvant dexamethasone or glycerol with placebo in children aged from 2 months through 16 years in Latin America. Ceftriaxone was administered to all children; children… CONTINUE READING

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Glycerol and bacterial meningitis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2007
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