Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10.

@article{Oliveira2013AdjuvantFT,
  title={Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10.},
  author={Vanessa G. Oliveira and Ana Agua-Doce and Maria A Curotto de Lafaille and Juan Jose Lafaille and Lu{\'i}s Afonso Graça},
  journal={Blood},
  year={2013},
  volume={121 19},
  pages={3936-45, S1}
}
Current treatment of hemophilia consists of the administration of recombinant clotting factors, such as factor VIII (FVIII). However, patients with severe hemophilia can mount immune responses targeting therapeutically administered FVIII through inhibitory immunoglobulins that limit treatment efficacy. Induction of immune tolerance to FVIII in hemophilia has been extensively studied but remains an unmet need. We found that nondepleting anti-CD4 monoclonal antibodies (mAbs) are effective in… CONTINUE READING
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