Adjuvant chemotherapy with sequential or concurrent anthracycline and docetaxel: Breast International Group 02-98 randomized trial.

@article{Francis2008AdjuvantCW,
  title={Adjuvant chemotherapy with sequential or concurrent anthracycline and docetaxel: Breast International Group 02-98 randomized trial.},
  author={Prudence A. Francis and John P. A. Crown and Angelo Leo and Marc Buyse and Ana Balil and Michael Andersson and B O Nordenskj{\"o}ld and Istv{\'a}n L{\'a}ng and Raimund Jakesz and Daniel Vorobiof and Jorge R. Guti{\'e}rrez and Guy van Hazel and Stella Dolci and Sophie Jamin and Belguendouz Bendahmane and Richard D. Gelber and Aron Goldhirsch and Monica Castiglione-Gertsch and Martine J. Piccart-Gebhart},
  journal={Journal of the National Cancer Institute},
  year={2008},
  volume={100 2},
  pages={121-33}
}
BACKGROUND Docetaxel is more effective than doxorubicin for patients with advanced breast cancer. The Breast International Group 02-98 randomized trial tested the effect of incorporating docetaxel into anthracycline-based adjuvant chemotherapy and compared sequential vs concurrent administration of doxorubicin and docetaxel. METHODS Patients with lymph node-positive breast cancer (n = 2887) were randomly assigned to one of four treatments: 1) sequential control (four cycles of doxorubicin at… CONTINUE READING
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