Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial.

@article{Fisher1986AdjuvantCW,
  title={Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial.},
  author={Bernard Fisher and Carol Redmond and Ann Marie Brown and Edwin R. Fisher and Norman Wolmark and David M. Bowman and David Plotkin and Janet Wolter and Robert Bornstein and S Legault-Poisson},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1986},
  volume={4 4},
  pages={459-71}
}
In this National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trial, 1,891 women with primary operable breast cancer and positive axillary nodes were randomized between Jan, 1977 and May 1980 to receive L-phenylalanine mustard (L-PAM) and 5-fluorouracil (5-FU) either with or without tamoxifen (TAM)-PFT. This report presents life table probabilities, cumulative odds ratios, and P values for disease-free survival (DFS) and survival at yearly intervals through 5 years of observation… CONTINUE READING