Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system.

@article{Lombardi2001AdjuvantAI,
  title={Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system.},
  author={Maria Stella Lombardi and Annemieke Kavelaars and Pieter M. Cobelens and Reinhold Ernst Schmidt and Manfred Schedlowski and Cobi J Heijnen},
  journal={Journal of immunology},
  year={2001},
  volume={166 3},
  pages={1635-40}
}
G protein-coupled receptors (GPCR) play a crucial role in the regulation of the immune response by, e.g., chemokines, PGs, and beta(2)-adrenergic agonists. The responsiveness of these GPCRs is turned off by the family of G protein-coupled receptor kinases (GRK1-6). These kinases act by phosphorylating the GPCR in an agonist-dependent manner, resulting in homologous desensitization of the receptor. Although GRKs are widely expressed throughout the body, leukocytes express relatively high levels… CONTINUE READING