Adjuvant arthritis as a model of inflammatory cachexia.

  title={Adjuvant arthritis as a model of inflammatory cachexia.},
  author={Ronenn Roubenoff and Lisa M Freeman and Donald E. Smith and Leslie W. Abad and Charles A Dinarello and Joseph J. Kehayias},
  journal={Arthritis and rheumatism},
  volume={40 3},
OBJECTIVE To determine whether adjuvant arthritis (AA) leads to changes in body composition and cytokine production similar to those seen in patients with rheumatoid arthritis. METHODS AA was induced in Lewis rats using Freund's complete adjuvant. Body cell mass was measured by determining the concentration of total exchangeable potassium using 42K gavage. Splenocyte production of interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) was measured by bioassay. Weight and food intake… CONTINUE READING


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