Adjuvant aromatase inhibitor therapy: outcomes and safety.

  title={Adjuvant aromatase inhibitor therapy: outcomes and safety.},
  author={Wolfgang Janni and Philip G Hepp},
  journal={Cancer treatment reviews},
  volume={36 3},
Adjuvant therapy with the third-generation aromatase inhibitors (AIs) anastrozole, letrozole, and exemestane has largely replaced the use of tamoxifen (TAM) as standard adjuvant endocrine treatment for postmenopausal women with hormone-sensitive early breast cancer. Treatment strategies investigated in large, randomized, well-controlled clinical studies include the use of an AI as an upfront replacement for TAM, as an alternative to continued treatment with TAM, and in the extended adjuvant… CONTINUE READING


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