Adjuvant activity of GP96 C-terminal domain towards Her2/neu DNA vaccine is fusion direction-dependent

@article{Pakravan2010AdjuvantAO,
  title={Adjuvant activity of GP96 C-terminal domain towards Her2/neu DNA vaccine is fusion direction-dependent},
  author={Nafiseh Pakravan and Seyed Mahmoud Hashemi and Zuhair Mohammad Hassan},
  journal={Cell Stress and Chaperones},
  year={2010},
  volume={16},
  pages={41-48}
}
The Her2 is one of tumor-associated antigens (TAA), regarded as an ideal target of immunotherapy. DNA encoding full-length or truncated rat Her2/neu have shown protective and therapeutics potentials against Her2/neu-expressing mammary tumors. However, the efficacy of active vaccination is limited since Her2 is a self-tolerated antigen. Hence, new strategies are required to enhance both the quality and quantity of the immune response against Her2-expressing tumors. Many studies have used Her2… CONTINUE READING
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