Adjuvant-Loaded Spiky Gold Nanoparticles for Activation of Innate Immune Cells

@article{Nam2017AdjuvantLoadedSG,
  title={Adjuvant-Loaded Spiky Gold Nanoparticles for Activation of Innate Immune Cells},
  author={Jutaek Nam and Sejin Son and James J Moon},
  journal={Cellular and Molecular Bioengineering},
  year={2017},
  volume={10},
  pages={341-355}
}
IntroductionGold nanoparticles are versatile carriers for delivery of biomacromolecules. Here, we have developed spiky gold nanoparticles (SGNPs) that can efficiently deliver immunostimulatory agents.ObjectivesOur goal was to develop a platform technology for co-delivery of multiple adjuvant molecules for synergistic stimulation and maturation of innate immune cells.MethodsSGNPs were synthesized by a seed-mediated, surfactant-free synthesis method and incorporated with polyinosinic… CONTINUE READING
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