Adjuvant Dabrafenib plus Trametinib in Stage III BRAF‐Mutated Melanoma

@article{Long2017AdjuvantDP,
  title={Adjuvant Dabrafenib plus Trametinib in Stage III BRAF‐Mutated Melanoma},
  author={Georgina V. Long and Axel Hauschild and Mario Santinami and Victoria G. Atkinson and Mario Mandal{\`a} and Vanna Chiarion-Sileni and James Larkin and Marta Nyakas and Caroline Dutriaux and Andrew Haydon and Caroline Robert and Laurent Mortier and Jacob Schachter and Dirk Schadendorf and Thierry Lesimple and Ruth Plummer and Ran Ji and Pingkuan Zhang and Bijoyesh Mookerjee and Jeffrey J. Legos and Richard F. Kefford and Reinhard Dummer and John M. Kirkwood},
  journal={The New England Journal of Medicine},
  year={2017},
  volume={377},
  pages={1813–1823}
}
BACKGROUND Combination therapy with the BRAF inhibitor dabrafenib plus the MEK inhibitor trametinib improved survival in patients with advanced melanoma with BRAF V600 mutations. We sought to determine whether adjuvant dabrafenib plus trametinib would improve outcomes in patients with resected, stage III melanoma with BRAF V600 mutations. METHODS In this double‐blind, placebo‐controlled, phase 3 trial, we randomly assigned 870 patients with completely resected, stage III melanoma with BRAF… 

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