Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms

@inproceedings{Diskin2008AdjustmentOG,
  title={Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms},
  author={Sharon J. Diskin and Mingyao Li and Cuiping Hou and Shuzhang Yang and Joseph T. Glessner and Hakon Hakonarson and Maja Bucan and John M. Maris and Kai Wang},
  booktitle={Nucleic acids research},
  year={2008}
}
Whole-genome microarrays with large-insert clones designed to determine DNA copy number often show variation in hybridization intensity that is related to the genomic position of the clones. We found these 'genomic waves' to be present in Illumina and Affymetrix SNP genotyping arrays, confirming that they are not platform-specific. The causes of genomic waves are not well-understood, and they may prevent accurate inference of copy number variations (CNVs). By measuring DNA concentration for… CONTINUE READING
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