Adjustment for local ancestry in genetic association analysis of admixed populations

@article{Wang2011AdjustmentFL,
  title={Adjustment for local ancestry in genetic association analysis of admixed populations},
  author={Xuexia Wang and Xiaofeng Zhu and Huaizhen Qin and Richard S. Cooper and Warren J. Ewens and Chun Li and Mingyao Li},
  journal={Bioinformatics},
  year={2011},
  volume={27 5},
  pages={670-7}
}
MOTIVATION Admixed populations offer a unique opportunity for mapping diseases that have large disease allele frequency differences between ancestral populations. However, association analysis in such populations is challenging because population stratification may lead to association with loci unlinked to the disease locus. METHODS AND RESULTS We show that local ancestry at a test single nucleotide polymorphism (SNP) may confound with the association signal and ignoring it can lead to… CONTINUE READING
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