Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

Abstract

In family-based association analysis, each family is typically ascertained from a single proband, which renders the effects of ascertainment bias heterogeneous among family members. This is contrary to case–control studies, and may introduce sample or ascertainment bias. Statistical efficiency is affected by ascertainment bias, and careful adjustment can… (More)
DOI: 10.1186/s12881-015-0198-6

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Cite this paper

@inproceedings{Park2015AdjustingHA, title={Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families}, author={Suyeon Park and Sungyoung Lee and Young Lee and Christine Herold and Basavaraj Hooli and Kristina Mullin and Taesung Park and Changsoon Park and Lars Bertram and Christoph Lange and Rudolph E. Tanzi and Sungho Won}, booktitle={BMC Medical Genetics}, year={2015} }