Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.

@article{Chaste2013AdjustingHC,
  title={Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.},
  author={Pauline Chaste and Lambertus Klei and Stephan J. Sanders and Michael T. Murtha and Vanessa H. Hus and Jennifer K. Lowe and A. Jeremy Willsey and Daniel Moreno-De-Luca and Timothy W. Yu and E. J. Fombonne and Daniel Geschwind and Dorothy E. Grice and David H. Ledbetter and C. Lord and Shrikant M. Mane and Christa Lese Martin and Donna M. Martin and Eric M. Morrow and Christopher A. Walsh and James S. Sutcliffe and Matthew W. State and Bernie J Devlin and Edwin H. Cook and Soo-jeong Kim},
  journal={Biological psychiatry},
  year={2013},
  volume={74 8},
  pages={576-84}
}
BACKGROUND Brain development follows a different trajectory in children with autism spectrum disorders (ASD) than in typically developing children. A proxy for neurodevelopment could be head circumference (HC), but studies assessing HC and its clinical correlates in ASD have been inconsistent. This study investigates HC and clinical correlates in the Simons Simplex Collection cohort. METHODS We used a mixed linear model to estimate effects of covariates and the deviation from the expected HC… CONTINUE READING
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