Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure.

@article{Tobin2005AdjustingFT,
  title={Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure.},
  author={Martin D Tobin and Nuala A Sheehan and Katrina Jacqueline Scurrah and Paul R. Burton},
  journal={Statistics in medicine},
  year={2005},
  volume={24 19},
  pages={2911-35}
}
A population-based study of a quantitative trait may be seriously compromised when the trait is subject to the effects of a treatment. For example, in a typical study of quantitative blood pressure (BP) 15 per cent or more of middle-aged subjects may take antihypertensive treatment. Without appropriate correction, this can lead to substantial shrinkage in the estimated effect of aetiological determinants of scientific interest and a marked reduction in statistical power. Correction relies upon… CONTINUE READING
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