Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk.

@article{Padilla2009AdjustingFD,
  title={Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk.},
  author={J. P. Torres Padilla and Blair D Johnson and Sean C. Newcomer and Daniel P. Wilhite and Timothy Derek Mickleborough and Alyce D. Fly and Kieren J Mather and Janet P. Wallace},
  journal={Journal of vascular research},
  year={2009},
  volume={46 6},
  pages={592-600}
}
BACKGROUND/AIMS Although normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress (FMD:shear stress ratio) has been proposed to improve this measure of endothelial function, the clinical utility of FMD normalization has not yet been demonstrated. We tested (1) whether following conventional 5-min forearm occlusion, the FMD:shear stress ratio would discriminate a population with moderate cardiovascular risk (MR) from a low-risk (LR) population, and (2) whether the… CONTINUE READING
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